The Icahn School of Medicine at Mount Sinai, formerly the Mount Sinai School of Medicine, is an American medical school in the borough of Manhattan in New York City. The Graduate School of Biomedical Sciences provides rigorous training in basic science and clinical research.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeDesign systems-level experiments using appropriate cutting edge techniques, collect big data, and analyze and interpret small and big data sets quantitatively.The Systems Biology Specialization covers the concepts and methodologies used in systems-level analysis of biomedical systems. Successful participants will learn how to use experimental, computational and mathematical methods in systems biology and how to design practical systems-level frameworks to address questions in a variety of biomedical fields. In the final Capstone Project, students will apply the methods they learned in five courses of specialization to work on a research project.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeAn introduction to dynamical modeling techniques used in contemporary Systems Biology research.We take a case-based approach to teach contemporary mathematical modelingtechniques. The course is appropriate for advanced undergraduates and beginning graduate students. Lectures provide biological background and describe the development of both classical mathematical models and more recent representations of biological processes. The course will be useful for students who plan to use experimental techniques as their approach in the laboratory and employ computational modeling as a tool to draw deeper understanding of experiments. The course should also be valuable as an introductory overview for students planning to conduct original research in modeling biological systems.This course focuses on dynamical modeling techniques used in Systems Biology research.These techniques are based on biological mechanisms, and simulations with these models generate predictions that can subsequently be tested experimentally. These testable predictions frequently provide novel insight into biological processes. The approaches taught here can be grouped into the following categories: 1) ordinary differential equation-based models, 2) partial differential equation-based models, and 3) stochastic models.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeA strong argument can be made that the health care field is one of the most information-intensive sectors in the U.S. economy and avoidance of the rapid advances in information technology is no longer an option. Consequently, the study of health care information technology and systems has become central to health care delivery effectiveness. This course covers the modern application of information technology that is critical to supporting the vision and operational knowledge of the health care leaders in managing the health care organization. Heath care decision-makers have to meet head-on the dynamic challenges of health care delivery quality, cost, access, and regulatory control. Additionally, this course integrates the Healthcare Information System as integral to the Quality Assurance Tracking Programs including measurement of systems inputs, processes, and outputs with special emphasis on systems outcomes research and organizational accountability to its various stakeholders, not the least of which are government regulators.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeThis course will focus on developing integrative skills through directed reading and analysis of the current primary literature to enable the student to develop the capstone project as the overall final exam for the specialization in systems biology.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeThe Library of Integrative Network-based Cellular Signatures (LINCS) is an NIH Common Fund program. The idea is to perturb different types of human cells with many different types of perturbations such as: drugs and other small molecules; genetic manipulations such as knockdown or overexpression of single genes; manipulation of the extracellular microenvironment conditions, for example, growing cells on different surfaces, and more. These perturbations are applied to various types of human cells including induced pluripotent stem cells from patients, differentiated into various lineages such as neurons or cardiomyocytes. Then, to better understand the molecular networks that are affected by these perturbations, changes in level of many different variables are measured including: mRNAs, proteins, and metabolites, as well as cellular phenotypic changes such as changes in cell morphology. The BD2K-LINCS Data Coordination and Integration Center (DCIC) is commissioned to organize, analyze, visualize and integrate this data with other publicly available relevant resources. In this course we briefly introduce the DCIC and the various Centers that collect data for LINCS. We then cover metadata and how metadata is linked to ontologies. We then present data processing and normalization methods to clean and harmonize LINCS data. This follow discussions about how data is served as RESTful APIs. Most importantly, the course covers computational methods including: data clustering, gene-set enrichment analysis, interactive data visualization, and supervised learning. Finally, we introduce crowdsourcing/citizen-science projects where students can work together in teams to extract expression signatures from public databases and then query such collections of signatures against LINCS data for predicting small molecules as potential therapeutics.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeThis course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeWelcome to Acute and Chronic Rhinosinusitis: A Comprehensive ReviewThis course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai, is designed to inform primary care physicians and general otolaryngologists, as well as nurses, physician assistants and medical assistants, about the differences between acute and chronic rhinosinusitis and how to distinguish and treat them. It is also applicable to individuals who wish to broaden their knowledge and vernacular about this disease process, especially those who may suffer from this condition. The course has been divided into four modules, each of which is followed by multiple choice questions to help attendees further understand this condition: Week 1 - CME Information, Accreditation and IntroductionWeek 2 - Module 1: Normal Sinus Anatomy and Function (15 min. + quiz)Week 3 - Module 2: Acute Rhinosinusitis: Diagnosis and Treatment (17 min. + quiz)Week 4 - Module 3: Chronic Rhinoinusitis: Diagnosis and Treatment (18 min. + quiz)Week 5 - Module 4: The Role of Surgery for Sinusitis and Activity Evaluation (36 min. + 2 quizzes)The primary objective of this course is to provide physicians with a thorough understanding of how to better diagnose and treat patients who suffer from acute and chronic rhinosinusitis.Those participating in this course have the option to receive CME credit.Please review the CME Information and Accreditation prior to proceeding with the course modules.Release Date: January 16, 2018Expiration Date: January 16, 2020Estimated Time to Complete: One Hour and Forty Five MinutesCME Fee: $30.00CME Credits Offered: 1.75CME Reviewer: Marita S. Teng, MDHow to Receive CME Credit:For physicians who are interested in earning CME credits and other allied health professions who wish to receive a Verification of Attendance certificate, you must:a. Complete Signature Track (details to follow after enrolling in this course)b. Complete registration process through the Icahn School of Medicine at Mount Sinai, CME Office using the following link: http://bit.ly/Acute_Chronic (WARNING: This course is no longer available for CME Credit.)(You will be required to pay an additional non-refundable fee of $30.00 in addition to the $49.00 fee for signature track.)c. Email an attached copy of your Verified Certificate from Coursera to the CME office at the Icahn School of Medicine at cme@mssm.edu and request your CME certificate.d. You will be provided with the instructions for downloading your CME/CE certificate.Technical Design and DevelopmentLynette BobbittLisa ChaseJill GregoryPaul LawrenceCharles PsarreasRory Sacks
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeWelcome to Voice Disorders: What Patients and Professionals Need to KnowKnowledge regarding vocal production physiology and management options for voice disorders have experienced rapid growth over the past 40 years.This growth has resulted in a knowledge gap amongst patients and practitioners. Entirely new subspecialties of laryngology under otolaryngology and vocology under speech-language pathology have developed in response to this gap.This MOOC (Massive Open Online Course) is designed to educated patients, allied healthcare providers, vocal trainers/coaches, general medical practitioners and otolaryngologists.Participants will be exposed to current concepts on the physiology of voice production.These physiologic principles will be applied to speaking and performance voice production styles. Building on the knowledge of efficient voice production methods, participants will learn how vocal inefficiencies can lead to the development of voice disorders.Finally, behavioral, medical and surgical management options and indications will be presented.The course has been divided into five modules, each of which is followed by multiple choice questions: Week 1 - CME Information, Accreditation and Introduction (2 min)Week 2 - Module 1: Basic Anatomy and Physiology of the Speaking and Singing Voice (29 min. + quiz) Week 3 - Module 2: Applied Physiology (Function) (20 min. + quiz) Week 4 - Module 3: Changes in Vocal Effort and Quality (20 min. + quiz) Week 5 - Module 4: Principles of Voice Evaluation and Examination (17 min. + quiz)Week 6 - Module 5: Medical or Surgical Intervention (33 min. + quiz) Those participating in this course have the option to receive CME credit. Please review the CME Information and Accreditation prior to proceeding with the course modules. Release Date: November 29, 2017Expiration Date: November 29, 2019Estimated Time to Complete: 3 hours CME Fee: $30 CME Credits Offered: 3.0 CME Reviewer: Marita S. Teng, MD How to Receive CME Credit:For physicians who are interested in earning CME credits and other allied health professions who wish to receive a Verification of Attendance certificate, you must: a. Complete Signature Track (details to follow after enrolling in this course) b. Complete registration process through the Icahn School of Medicine at Mount Sinai, CME Office using the following link:https://mssm.cloud-cme.com/default.aspx?EID=9&P=3000&CaseID=2 (WARNING: This course is no longer available for CME Credit.)(You will be required to pay an additional non-refundable fee of $30.00 in addition to the $49.00 fee for signature track.) c. Email an attached copy of your Verified Certificate from Coursera to the CME office at the Icahn School of Medicine at cme@mssm.edu and request your CME certificate.d. You will be provided with the instructions for downloading your CME/CE certificate.Course Planners Lynette BobbittMark S. Courey, MDLisa ChaseJill GregoryGale JustinPaul LawrenceErik PopilChristopher SmithKelly ZerellaAmy Zhong
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeThe course is a comprehensive set of didactic lectures surveying fundamentals of transgender medical and surgical treatment.The material is meant to provide the student with core knowledge that is essential for current primary care providers caring for transgender patients.There are 10 modules led by the expert clinical faculty from the pioneering Center for Transgender Medicine and Surgery, located within the Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai in New York City.The course begins with an introduction to frame the sea change that has taken place in the current medical practice of transgender health care. Subsequent modules allow individuals to learn key elements necessary to provide quality transgender medical care. As a whole, the modules provide an opportunity to develop a knowledgeable approach to behavioral health, primary care, hormone therapy, and the surgical options.Module 1: Introduction -Joshua D SaferModule 2: Making the Determination - Hansel ArroyoModule 3: Primary Care for Transgender Women - Zil GoldsteinModule 4: Primary Care for Transgender Men - Zil GoldsteinModule 5: What are the Essential Strategies to Transgender Hormone Therapy? -Joshua D SaferModule 6: Initiation and Maintenance of Hormones for the Trans Masculine Patient - Joshua D SaferModule 7: Initiation and Maintenance of Hormones for the Trans Feminine Patient -Joshua D SaferModule 8: Transgender Surgery: Chest & Face - Bella K AvanessianModule 9: Transmasculine Genital Surgery - Bella K AvanessianModule 10: Transfeminine Genital Surgery - Bella K Avanessian
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeWelcome to HPV-Associated Oral and Throat Cancers: What You Need to Know This course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai, is designed to inform primary care physicians and otolaryngologists (general and head and neck surgeons), as well as medical students, residents, nurses, physician assistants, medical assistants, about HPV-associated oral and throat cancers. It is also applicable to individuals who wish to broaden their knowledge and vernacular about this disease process, especially those who may have been diagnosed with HPV and/or HPV-associated oropharyngeal cancers. The course has been divided into four modules, each of which is followed by multiple choice questions to help attendees further understand this condition: Week 1 - CME Information, Accreditation and Introduction (2 min)Week 2 - Module 1: HPV-associated Throat Cancer: An Epidemic (11 min. + quiz) Week 3 - Module 2: HPV Risk Factors and Clinical Presentation (10 min. + quiz) Week 4 - Module 3: Management of HPV-associated Oropharyngeal Cancer (13 min. + quiz) Week 5 - Module 4: Prevention, Vaccination, and the Horizon (10 min. + quiz) The primary objective of this course is to provide physicians with a thorough understanding of how to better diagnose and treat patients who have HPV-related oral and throat cancers. Those participating in this course have the option to receive CME credit. Please review the CME Information and Accreditation prior to proceeding with the course modules. Release Date: February 4, 2019Expiration Date: February 4, 2021Estimated Time to Complete: 1 hour CME Fee: $30 CME Credits Offered: 1.0 CME Reviewer: Marita S. Teng, MD How to Receive CME Credit:For physicians who are interested in earning CME credits and other allied health professions who wish to receive a Verification of Attendance certificate, you must: a. Complete Signature Track (details to follow after enrolling in this course) b. Complete registration process through the Icahn School of Medicine at Mount Sinai, CME Office using the following link:https://mssm.cloud-cme.com/default.aspx?EID=4177&P=3000&CaseID=78(You will be required to pay an additional non-refundable fee of $30.00 in addition to the $49.00 fee for signature track.)c. Email an attached copy of your Verified Certificate from Coursera to the CME office at the Icahn School of Medicine at cme@mssm.edu and request your CME certificate.d. You will be provided with the instructions for downloading your CME/CE certificate.Course Planners Lynette BobbittLisa ChaseEric M. Genden, MD Jill GregoryGale JustinPaul LawrenceCarter LimErik Popil
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeWelcome to Introduction to Hearing LossDisorders of the ear range from simple, easily treated entities (such as wax or cerumen impaction) to the highly complex (such as permanent hearing loss).Many of these disorders manifest with similar symptoms and may be difficult to differentiate without a basic understanding of the anatomy of the ear and auditory pathway. This course, offered by the Department of Otolaryngology – Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, presents the basic anatomy of the ear from the auricle or outer ear to the brain. The pathophysiology of each type of hearing loss is presented and common pathology in each of the three areas of the ear (outer, middle and inner) are reviewed. Participants will become familiar with the structural and cellular anatomy in each area, as well as the underlying pathophysiology for various disorders. They will also gain an understanding of available treatments for various ear conditions.Week 1: IntroductionWeek 2: Anatomy and pathophysiology of the auditory pathway (15 min. + quiz)Week 3: Disorders and treatments of the outer ear (15 min. + quiz) Week 4: Disorders and treatments of the middle ear (15 min. + quiz)Week 5: Disorders and treatments of the inner ear (15 min. + quiz)The primary objectives of this course are to:•Recognize the functional and cellular anatomy of the auditory pathway•Understand the types of hearing loss and common causes of each type•Demonstrate familiarity with disorders of the outer, middle and inner earThose participating in this course have the option to complete the course at no cost or receive the Coursera Signature Track Certificate for $49.95. Course Planners:Lisa ChaseNi-ka FordJill GregoryGale Justin Paul Lawrence Erik PopilKelly ZerellaAmy ZhongTaught By: Maura Cosetti, MDAssistant ProfessorOtolaryngology - Head and Neck Surgery Icahn School of Medicine at Mount Sinai Director, Cochlear Implant Program Ear Institute at New York Eye and Ear Infirmary of Mount SinaiMount Sinai Health System
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeLearn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging.A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content.
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeNOTE: In order to take this course you should have taken and complete the following courses in the Signature Track: Introduction to Systems Biology, Network Analysis in Systems Biology, Dynamical Modeling Methods for Systems Biology, Experimental Methods in SB and Integrated Analysis In Systems Biology
Class Central TipsLearn How to Sign up to Coursera courses for free1600+ Coursera Courses That Are Still Completely FreeAn introduction to data integration and statistical methods used in contemporary Systems Biology, Bioinformatics and Systems Pharmacology research. The course covers methods to process raw data from genome-wide mRNA expression studies (microarrays and RNA-seq) including data normalization, differential expression, clustering, enrichment analysis and network construction. The course contains practical tutorials for using tools and setting up pipelines, but it also covers the mathematics behind the methods applied within the tools. The course is mostly appropriate for beginning graduate students and advanced undergraduates majoring in fields such as biology, math, physics, chemistry, computer science, biomedical and electrical engineering. The course should be useful for researchers who encounter large datasets in their own research. The course presents software tools developed by the Ma’ayan Laboratory (http://labs.icahn.mssm.edu/maayanlab/) from the Icahn School of Medicine at Mount Sinai, but also other freely available data analysis and visualization tools. The ultimate aim of the course is to enable participants to utilize the methods presented in this course for analyzing their own data for their own projects. For those participants that do not work in the field, the course introduces the current research challenges faced in the field of computational systems biology.